CALL FOR PAPERS Sex and Gender Differences in Renal Physiology Transdermal contraception and the renin-angiotensin-aldosterone system in premenopausal women
نویسندگان
چکیده
Ayodele Odutayo, David Cherney,* Judith Miller, Sofia B. Ahmed, Vesta Lai, Sheila Dunn, Nicole Pun, Rahim Moineddin, and Michelle A. Hladunewich* Division of Nephrology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada; University Health Network, University of Toronto, Toronto, Ontario, Canada; University of Calgary, Calgary, Alberta, Canada; Department of Family and Community Medicine, Women’s College Hospital, University of Toronto, Toronto, Ontario, Canada; and The Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada
منابع مشابه
Transdermal contraception and the renin-angiotensin-aldosterone system in premenopausal women.
The oral contraceptive pill (OCP) activates the renin-angiotensin-aldosterone system (RAAS) through first-pass hepatic metabolism. Although usually benign, RAAS activation may have detrimental effects on renal and hemodynamic function in some women. Since combined hormonal contraception with the transdermal patch (EVRA) does not undergo first-pass hepatic metabolism, we hypothesized that the RA...
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OBJECTIVE Several studies reported gender differences in aldosterone. It is unknown whether these differences are associated with differences in volume regulation. Therefore, we studied both aldosterone and extracellular volume in men and women on different sodium intakes. METHODS In healthy normotensive men (n=18) and premenopausal women (n=18) we investigated plasma aldosterone, blood pressur...
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Premenopausal women have lower blood pressure and a reduced incidence of cardiovascular disease compared with age-matched men. Similar sex differences have been seen across species and in multiple animal models of hypertension. While important progress over the last decade has been made in elucidating some of the mechanisms underlying these differences, there are still significant gaps in our k...
متن کاملRenin-angiotensin system and unilateral ureteral obstruction
Unilateral ureteral obstruction (UUO) is a clinical scenario that leads to obstructive nephropathy. UUO alters the expression of many mediators in the ipsilateral kidney. Renin-angiotensin system (RAS) is involved in UUO. Angiotensin II (Ang II) and angiotensin 1-7 (Ang 1-7) as the main arms of RAS influence kidney function which may alter by UUO. Ang II via Ang II receptor subtypes I (AT1R) ...
متن کاملEffect of oral contraceptives on the renin angiotensin system and renal function.
We examined the effect of oral contraceptive (OC) usage on the renin angiotensin system (RAS) in two related experiments. In the first experiment, subjects were 34 healthy, normotensive, premenopausal women, 15 OC users and 19 OC nonusers, mean age 25 +/- 1 yr, ingesting a controlled sodium diet. We assessed arterial pressure, glomerular filtration rate, effective renal plasma flow, renal vascu...
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